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International Journal of Sports Medicine Mar 2022High-intensity training is becoming increasingly popular outside of elite sport for health prevention and rehabilitation. This expanded application of high-intensity... (Review)
Review
High-intensity training is becoming increasingly popular outside of elite sport for health prevention and rehabilitation. This expanded application of high-intensity training in different populations requires a deeper understanding of its molecular signature in the human body. Therefore, in this integrative review, cellular and systemic molecular responses to high-intensity training are described for skeletal muscle, cardiovascular system, and the immune system as major effectors and targets of health and performance. Different kinds of stimuli and resulting homeostatic perturbations (i. e., metabolic, mechanical, neuronal, and hormonal) are reflected, taking into account their role in the local and systemic deflection of molecular sensors and mediators, and their role in tissue and organ adaptations. In skeletal muscle, a high metabolic perturbation induced by high-intensity training is the major stimulus for skeletal muscle adaptation. In the cardio-vascular system, high-intensity training induces haemodynamic stress and deflection of the Cahandling as major stimuli for functional and structural adaptation of the heart and vessels. For the immune system haemodynamic stress, hormones, exosomes, and O availability are proposed stimuli that mediate their effects by alteration of different signalling processes leading to local and systemic (anti)inflammatory responses. Overall, high-intensity training shows specific molecular signatures that demonstrate its high potential to improve health and physical performance.
Topics: Acclimatization; Adaptation, Physiological; Human Body; Humans; Muscle, Skeletal; Sports
PubMed: 34265857
DOI: 10.1055/a-1551-9294 -
Sensors (Basel, Switzerland) Jun 2019The world's population is aging: the expansion of the older adult population with multiple physical and health issues is now a huge socio-economic concern worldwide.... (Review)
Review
The world's population is aging: the expansion of the older adult population with multiple physical and health issues is now a huge socio-economic concern worldwide. Among these issues, the loss of mobility among older adults due to musculoskeletal disorders is especially serious as it has severe social, mental and physical consequences. Human body joint monitoring and early diagnosis of these disorders will be a strong and effective solution to this problem. A smart joint monitoring system can identify and record important musculoskeletal-related parameters. Such devices can be utilized for continuous monitoring of joint movements during the normal daily activities of older adults and the healing process of joints (hips, knees or ankles) during the post-surgery period. A viable monitoring system can be developed by combining miniaturized, durable, low-cost and compact sensors with the advanced communication technologies and data processing techniques. In this study, we have presented and compared different joint monitoring methods and sensing technologies recently reported. A discussion on sensors' data processing, interpretation, and analysis techniques is also presented. Finally, current research focus, as well as future prospects and development challenges in joint monitoring systems are discussed.
Topics: Aged; Biomechanical Phenomena; Female; Human Body; Humans; Joints; Monitoring, Physiologic; Movement; Range of Motion, Articular; Wearable Electronic Devices
PubMed: 31185629
DOI: 10.3390/s19112629 -
Scientific Reports May 2024Every human has a body. Yet, languages differ in how they divide the body into parts to name them. While universal naming strategies exist, there is also variation in...
Every human has a body. Yet, languages differ in how they divide the body into parts to name them. While universal naming strategies exist, there is also variation in the vocabularies of body parts across languages. In this study, we investigate the similarities and differences in naming two separate body parts with one word, i.e., colexifications. We use a computational approach to create networks of body part vocabularies across languages. The analyses focus on body part networks in large language families, on perceptual features that lead to colexifications of body parts, and on a comparison of network structures in different semantic domains. Our results show that adjacent body parts are colexified frequently. However, preferences for perceptual features such as shape and function lead to variations in body part vocabularies. In addition, body part colexification networks are less varied across language families than networks in the semantic domains of emotion and colour. The study presents the first large-scale comparison of body part vocabularies in 1,028 language varieties and provides important insights into the variability of a universal human domain.
Topics: Humans; Language; Semantics; Vocabulary; Human Body; Culture
PubMed: 38714717
DOI: 10.1038/s41598-024-61140-0 -
International Journal of Surgery... May 2017Transplanting a head and brain is perhaps the final frontier of organ transplantation. The goal of body-to-head transplantation (BHT) is to sustain the life of... (Review)
Review
Transplanting a head and brain is perhaps the final frontier of organ transplantation. The goal of body-to-head transplantation (BHT) is to sustain the life of individuals who suffer from terminal disease, but whose head and brain are healthy. Ideally BHT could provide a lifesaving treatment for several conditions where none currently exists. BHT is no ordinary experiment, to transfer a head to another body involves extraordinarily complex medical challenges as well as ethical and existential dilemmas that were previously confined to the imagination of writers of fiction. The possibility of replacing an incurably ill body with a healthy one tests not only our surgical limits, but also the social and psychological boundaries of physical life and alters what we recognize life to be. The purpose of this target article, the complementary manuscript focused on immunological issues in BHT, and the accompanying Commentaries by scholars and practitioners in medicine, immunology, and bioethics is to review major surgical and psychosocial-ethical and immunological considerations surrounding body-to-head transplantation. We hope that together these ideas will provide readers with a comprehensive overview of the possibilities and challenges associated with BHT and initiate professional discussion and debate through which this new frontier in medicine is considered and approached.
Topics: Brain Tissue Transplantation; Head; Human Body; Humans; Organ Transplantation; Transplantation, Homologous
PubMed: 28110028
DOI: 10.1016/j.ijsu.2017.01.077 -
Proceedings of the National Academy of... May 2023Circadian rhythms influence physiology, metabolism, and molecular processes in the human body. Estimation of individual body time (circadian phase) is therefore highly...
Circadian rhythms influence physiology, metabolism, and molecular processes in the human body. Estimation of individual body time (circadian phase) is therefore highly relevant for individual optimization of behavior (sleep, meals, sports), diagnostic sampling, medical treatment, and for treatment of circadian rhythm disorders. Here, we provide a partial least squares regression (PLSR) machine learning approach that uses plasma-derived metabolomics data in one or more samples to estimate dim light melatonin onset (DLMO) as a proxy for circadian phase of the human body. For this purpose, our protocol was aimed to stay close to real-life conditions. We found that a metabolomics approach optimized for either women or men under entrained conditions performed equally well or better than existing approaches using more labor-intensive RNA sequencing-based methods. Although estimation of circadian body time using blood-targeted metabolomics requires further validation in shift work and other real-world conditions, it currently may offer a robust, feasible technique with relatively high accuracy to aid personalized optimization of behavior and clinical treatment after appropriate validation in patient populations.
Topics: Male; Humans; Female; Human Body; Light; Circadian Rhythm; Sleep; Melatonin; Metabolomics
PubMed: 37094145
DOI: 10.1073/pnas.2212685120 -
Magnetic Resonance in Medicine May 2022The use of high-performance gradient systems (i.e., high gradient strength and/or high slew rate) for human MRI is limited by physiological effects (including the...
PURPOSE
The use of high-performance gradient systems (i.e., high gradient strength and/or high slew rate) for human MRI is limited by physiological effects (including the elicitation of magnetophosphenes and peripheral nerve stimulation (PNS)). These effects, in turn, depend on the interaction between time-varying magnetic fields and the body, and thus on the participant's position with respect to the scanner's isocenter. This study investigated the occurrence of magnetophosphenes and PNS when scanning participants on a high-gradient (300 mT/m) system, for different gradient amplitudes, ramp times, and participant positions.
METHODS
Using a whole-body 300 mT/m gradient MRI system, a cohort of participants was scanned with the head, heart, and prostate at magnet isocenter and a train of trapezoidal bipolar gradient pulses, with ramp times from 0.88 to 4.20 ms and gradient amplitudes from 60 to 300 mT/m. Reports of magnetophosphenes and incidental reports of PNS were obtained. A questionnaire was used to record any additional subjective effects.
RESULTS
Magnetophosphenes were strongly dependent on participant position in the scanner. 87% of participants reported the effect with the heart at isocenter, 33% with the head at isocenter, and only 7% with the prostate at isocenter. PNS was most widely reported by participants for the vertical gradient axis (67% of participants), and was the dominant physiological effect for ramp times below 2 ms.
CONCLUSION
This study evaluates the probability of eliciting magnetophosphenes during whole-body imaging using an ultra-strong gradient MRI system. It provides empirical guidance on the use of high-performance gradient systems for whole-body human MRI.
Topics: Human Body; Humans; Magnetic Fields; Magnetic Resonance Imaging; Male; Probability
PubMed: 34932236
DOI: 10.1002/mrm.29118 -
Journal of Healthcare Engineering 2021As traditional Chinese medicine (TCM) has gained more and more recognition in the world, Chinese medicine has also played its important role. However, traditional...
As traditional Chinese medicine (TCM) has gained more and more recognition in the world, Chinese medicine has also played its important role. However, traditional Chinese medicine equipment is relatively deficient, with insufficient functions and low degree of digitalization. For example, existing auscultation equipment can obtain few human characteristic indicators, which is difficult to meet the needs of reference in traditional Chinese medicine diagnosis. Based on this, this paper designed a human body characteristic index detection system based on the principle of traditional Chinese medicine, which includes respiratory and heartbeat signal acquisition device, meridian and acupoint signal acquisition device, temperature signal acquisition device, pulse and blood pressure acquisition device, processing module, keyword module, and output module. The respiratory and heartbeat signal acquisition device is used to collect the respiratory and heartbeat signal of human body. Meridian acupoint signal acquisition device is used to collect human meridian acupoint radio signals. The temperature signal acquisition device is used to collect the infrared temperature light wave signal of human body. Pulse and blood pressure acquisition devices are used to collect pulse and blood pressure signals. The processing module is used to obtain one or more human body characteristic indicators according to one or more of the respiration and heartbeat signals, meridians and acupoints signals, temperature signals, pulse, and blood pressure, including Qi and blood characteristic indicators, viscera and six meridian characteristic indicators, and temperature characteristic indicators. The keyword corresponding module is used to obtain the corresponding keyword representing the physiological state information of human body according to the one or more human body characteristic indicators. The output module is used to output the human body characteristic index and the key words. It includes the key words of Qi and blood state information, the key words of viscera state information, the key words of Qi and blood state information, etc. The system can be used for serious disease screening, chronic disease management, and risk early warning.
Topics: Acupuncture Points; Heart Rate; Human Body; Humans; Medicine, Chinese Traditional; Meridians
PubMed: 33986941
DOI: 10.1155/2021/5549842 -
Sensors (Basel, Switzerland) Apr 2013The technology of sensor, pervasive computing, and intelligent information processing is widely used in Body Sensor Networks (BSNs), which are a branch of wireless... (Review)
Review
The technology of sensor, pervasive computing, and intelligent information processing is widely used in Body Sensor Networks (BSNs), which are a branch of wireless sensor networks (WSNs). BSNs are playing an increasingly important role in the fields of medical treatment, social welfare and sports, and are changing the way humans use computers. Existing surveys have placed emphasis on the concept and architecture of BSNs, signal acquisition, context-aware sensing, and system technology, while this paper will focus on sensor, data fusion, and network communication. And we will introduce the research status of BSNs, the analysis of hotspots, and future development trends, the discussion of major challenges and technical problems facing currently. The typical research projects and practical application of BSNs are introduced as well. BSNs are progressing along the direction of multi-technology integration and intelligence. Although there are still many problems, the future of BSNs is fundamentally promising, profoundly changing the human-machine relationships and improving the quality of people's lives.
Topics: Computer Communication Networks; Human Body; Humans; Man-Machine Systems; Wireless Technology
PubMed: 23615581
DOI: 10.3390/s130505406 -
International Journal of Environmental... Sep 2022This manuscript offers findings from a pilot project which prepares nursing students for embodied professional practice through the lens of ethics. Four undergraduate...
This manuscript offers findings from a pilot project which prepares nursing students for embodied professional practice through the lens of ethics. Four undergraduate nursing students were mentored by two nursing faculty in the Dundon-Berchtold Institute Faculty Fellowship Program in the Application of Ethics through an exploration on the ethics of embodiment using an arts pedagogy across one academic year. Inspired by the intersection of nature and health, this project explores the impact of an arts-integrated pedagogy on the human body. The findings from this project provide a natural first step for nursing students to consider multiple interpretations of the human body and to facilitate the students' development of an embodied ethical practice that is perceptive, empathic, and attuned to themselves as natural beings as well as diverse individuals and populations. The findings from this pilot project presents a pivotal opportunity to guide future nursing curricular development toward holistic, nature-inspired, and mindful-based interventions in order to increase resilience, decrease risk factors of compassion fatigue and burnout, and support nursing students to develop strength-based skills to use in their professional nursing practice.
Topics: Education, Nursing, Baccalaureate; Faculty, Nursing; Human Body; Humans; Pilot Projects; Students, Nursing
PubMed: 36141876
DOI: 10.3390/ijerph191811603 -
British Journal of Psychology (London,... Aug 2022The way human bodies are represented is central in everyday activities. The cognitive system must combine internal, visceral, and somatosensory, signals to external,...
The way human bodies are represented is central in everyday activities. The cognitive system must combine internal, visceral, and somatosensory, signals to external, visually driven information generated from the spatial placement of others' bodies and the own body in the space. However, how different body representations covertly interact among them when observing human body parts is still unclear. Therefore, we investigated the implicit processing of body parts by manipulating either the body part stimuli' posture (conditions a and b) or the participants' response body posture (conditions c, d, and e) in healthy participants (N = 70) using a spatial compatibility task called Sidedness task. The task requires participants to judge the colour of a circle superimposed on a task-irrelevant body part picture. Responses are facilitated when the spatial side of the responding hand corresponds to the spatial code generated by the hand stimulus's position with respect to a body of reference. Results showed that the observation of the task-irrelevant body parts oriented participants' attention and facilitated responses that were spatial compatible with the spatial position such body parts have within a configural representation of the body structure (i.e., Body Structural Representation) in all the five experimental conditions. Notably, the body part stimuli were mentally attached to the body according to the most comfortable and less awkward postures, following the anatomo-physiological constraints. Moreover, the pattern of the results was not influenced by manipulating the participants' response postures, suggesting that the automatic and implicit coding of the body part stimuli does not rely on proprioceptive information about one's body (i.e., Body Schema). We propose that the human body's morphometry knowledge is enriched by biomechanical and anatomo-physiological information about the real body movement possibilities. Moreover, we discuss the importance of the automatic orienting of attention based on the sidedness within the context of imitational learning.
Topics: Body Image; Human Body; Humans; Movement; Posture; Proprioception
PubMed: 35181883
DOI: 10.1111/bjop.12558